VARIOLA VIRUS Essay examples -- Essays Papers

VARIOLA VIRUSSMALLPOX INTRODUCTION The variola computer virus, which is the most(prenominal) virulent member of Genus Orthopoxvirus, is the causative component of smallpox. It specifically infects humans. The uncreated reason for infection in humans is due to its ability to hedge the host immune responses, and avoid complement activation. Over the centuries, this naturally occurring virus has spread throughout the earth, through various environments, to cause severe outbreaks. The most devastation outbreak had a case-fatality esteem of 40 percent in individuals who assimilate not been vaccinated.The Variola virus is a double-stranded DNA virus. It has ii envelopes the outmost envelope is present only in the extracellular state. The outer surface or the core membrane, which surrounds the core of the virus, contains lipids and proteins and has a complex symmetry. The core, which has a dumbbell-shape, contains a large amount of the double-stranded DNA (186kbp), about 10 enzymes to liaise gene expression and lots of nucleoproteins- both specific and everyday. These proteins are regard in DNA transcription, as well as inducing cross-reactive license (IOM, 1999). The space outside the core contains lateral bodies which do not have any known functions. There are two forms of the variola virus variola major and variola nipper. Variola major is the lethal strain, slice variola minor is not lethal, but a mild strain, which is in truth similar to major but is only genetically different. The most common strain is the variola major, which produces the more severe symptoms, and with a fatality rate of 20% to 40%, within the 7th day of infection. The variola minor is the milder form of the disease that has a death rate of less than 1%. Surviving infection from... ...o, Pere, MD. Smallpox The Triumph Over the Most stern of the Ministers of Death. Annals of Internal Medicine. 1997 127635- 42. Ellner, P.D. Smallpox Gone but Not Forgotten. Infection. 1998 26 (5) 263-9.CDC overview www.bt.cdc.gov/agent/smallpox/vaccination/facts.aspCDC overview2 www.bt.cdc.gov/agent/smallpox/overview/disease-facts.aspCDC vaccine www.bt.cdc.gov/agent/smallpox/vaccination/contraindictions-public.aspKoplow, David. Smallpox The Fight to Eradicate a international Scourge. 2003IOM(Institute of Medicine) Live Variola Virus committee on the assessment of future tense Scientific needs for live variola virus. National Academy charge up 1999.Mayo Foundation for Medical Education and Research (MFMER). October 1, 2002http//www.mayoclinic.com/invoke.cfm?id=ds00424Nature Reviews Immunology 2, 544 (2002) inside10.1038/nri868